C.K 492001 Electricians Scissors

£8.995
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C.K 492001 Electricians Scissors

C.K 492001 Electricians Scissors

RRP: £17.99
Price: £8.995
£8.995 FREE Shipping

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Price MA, Kalderon D: Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell. 2002, 108: 823-835. 10.1016/S0092-8674(02)00664-5 Graves PR, Roach PJ: Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta. J Biol Chem. 1995, 270: 21689-21694. 10.1074/jbc.270.37.21689 Dejmek J, Säfholm A, Kamp Nielsen C, Andersson T, Leandersson K: Wnt-5a/Ca2 + −induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol. 2006, 26: 6024-6036. 10.1128/MCB.02354-05 Wang L, Lu A, Zhou H-X, Sun R, Zhao J, Zhou C-J, Shen J-P, Wu S-N, Liang C-G: Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development. PLoS One. 2013, 8: e63173- 10.1371/journal.pone.0063173

Waugh MG, Challiss RA, Berstein G, Nahorski SR, Tobin AB: Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors. Biochem J. 1999, 338 (Pt 1): 175-183.

Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, Berger AJ, Major MB, Hwang ST, Rimm DL, Moon RT: Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A. 2009, 106: 1193-1198. 10.1073/pnas.0811902106 Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012, 2: 401-404. 10.1158/2159-8290.CD-12-0095

Järås M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL: Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med. 2014, 211: 605-612. 10.1084/jem.20131033 Sinnberg T, Menzel M, Kaesler S, Biedermann T, Sauer B, Nahnsen S, Schwarz M, Garbe C, Schittek B: Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis. Cancer Res. 2010, 70: 6999-7009. 10.1158/0008-5472.CAN-10-0645 Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X: Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 2002, 108: 837-847. 10.1016/S0092-8674(02)00685-2 For over 100 years, C.K has been at the forefront of hand tool manufacturing, producing high quality tools that meet the most demanding needs of trade professionals.Sarasqueta AF, Forte G, Corver WE, de Miranda NF, Ruano D, van Eijk R, Oosting J, Tollenaar RAEM, van Wezel T, Morreau H: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. BMC Cancer. 2013, 13: 277- 10.1186/1471-2407-13-277 Fuja TJ, Lin F, Osann KE, Bryant PJ: Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res. 2004, 64: 942-951. 10.1158/0008-5472.CAN-03-2100 Yu DH, Macdonald J, Liu G, Lee AS, Ly M, Davis T, Ke N, Zhou D, Wong Staal F, Li QX: Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS One. 2008, 3: e3951- 10.1371/journal.pone.0003951

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Please note:

Knippschild U, Milne DM, Campbell LE, DeMaggio AJ, Christenson E, Hoekstra MF, Meek DW: p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene. 1997, 15: 1727-1736. 10.1038/sj.onc.1201541 Carvalho G, Le Guelte A, Demian C, Vazquez A, Gavard J, Bidère N: Interplay between BCL10, MALT1 and IkappaBalpha during T-cell-receptor-mediated NFkappaB activation. J Cell Sci. 2010, 123 (Pt 14): 2375-2380. Zhao Y, Qin S, Atangan LI, Molina Y, Okawa Y, Arpawong HT, Ghosn C, Xiao J-H, Vuligonda V, Brown G, Chandraratna RAS: Casein kinase 1alpha interacts with retinoid X receptor and interferes with agonist-induced apoptosis. J Biol Chem. 2004, 279: 30844-30849. 10.1074/jbc.M404651200



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