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iThera Medical has developed Multispectral Optoacoustic Tomography (MSOT), a breakthrough imaging technology that utilizes the photoacoustic effect – describing the conversion of light energy into sound waves – to visualize optical contrast, at high resolution in deep tissue.
Ulrich Kruse, Investment Manager of Trumpf Venture, commented, “iThera Medical’s technology is positioned to be the next breakthrough in medical imaging. As a company with deep roots in photonics and medical technology, we are thrilled to support the continued development of MSOT and anticipate an impactful launch into wider medical imaging markets.”Ku, G., Wang, X., Xie, X., Stoica, G. & Wang, L. V. Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography. Appl. Opt. 44, 770–775 (2005).
iTHERAU Large Infrared Light Therapy Belt is an innovative product that uses advanced technology to distribute 360 LED beads on a 31.49*11.81 inch extra-large treatment pad, each bead inside has three chips, emitting 660nm red light and 850nm infrared light respectively. Herzog, E. et al. Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography. Radiology. 263, 461–468 (2012).Rouleau, L. et al. VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice. Contrast Media Mol. Imag. 8, 27–39 (2013). van Leengoed, H. L. L. M. et al. In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes. Br. J. Cancer. 69, 840–845 (1994). ZnPc at a dosage of 0.21 mg/kg was injected via a catheter into the tail vein of tumor-bearing mice anaesthetized under isoflurane and the probe biodistribution was monitored over time in various organs using PA imaging. Before image acquisition, a volume ROI consisting of transverse slices with a step size of 0.3 mm spanning from the liver to the lower abdomen was selected by manual inspection of live MSOT images and the 6 laser excitation wavelengths of 680, 700, 750, 800, 850 and 900 nm were selected for correspondence with the major turning points in the absorption spectra of ZnPc, oxy- and deoxy-haemoglobin. Multispectral imaging was then performed with 10 signal averages per wavelength per transverse slice, before injection, during injection and 1, 3, 5 and 24 hr postinjection. Image reconstruction and multispectral processing Panel A shows the transabdominal imaging approach, which uses the same detector for laser light emission and ultrasonic detection of signal levels by means of multispectral optoacoustic tomography (MSOT). Erythrocytes are the target for laser-light absorption and ultrasonic emission. Six different wavelengths (700, 730, 760, 800, 850, and 900 nm) were used for MSOT data acquisition; MSOT measurements, such as total hemoglobin (Hb), oxygenated Hb, deoxygenated Hb, and oxygen saturation, are calculated from these measurements. These hemoglobin-based measurements permit the evaluation of tissue perfusion and oxygenation as surrogates of inflammation with MSOT. Panel B shows MSOT-derived total Hb signal levels in the intestinal wall (in both the large bowel and the small intestine) in 44 patients with Crohn’s disease with different degrees of endoscopic inflammation. Such evaluation was performed by means of the Simplified Endoscopic Score for Crohn’s Disease (SES-CD), which ranges from 0 to 56, with higher scores indicating a greater severity of intestinal inflammation; remission is defined as a score of less than 3, low disease activity as a score of 3 to 6, moderate disease activity as a score of 7 to 15, and high disease activity as a score of 16 or more. The signal levels are expressed as normalized z scores and transformed into a linear scale of arbitrary units (au). The red dots represent single measurements for each patient; the horizontal lines indicate medians, and I bars the interquartile range. A single asterisk denotes P<0.05 and a double asterisk P<0.001 for the comparison with remission. Panel C shows representative images of MSOT measurements of total Hb in the large bowel and small intestine in patients with different grades of endoscopic disease activity (as evaluated by means of SES-CD). The top row shows representative MSOT measurements of total Hb as color-coded maps with an overlay of B-mode ultrasonographic images. The middle row shows schematic representations of the images shown in the top row. The bottom row shows the corresponding endoscopic evaluation. Christian Wiest, CEO and co-founder of iThera Medical, said, “This funding round is the next major step to translate our MSOT technology from a tool in research to a diagnostic asset in a clinical setting, where we believe it will be a game-changer for millions of patients worldwide.”
Yang, H.-W. et al. Magnetic gold-nanorod/PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy. Biomaterials 34, 5651–5660 (2013). The co-investment by the EIC Fund comes as the equity portion of iThera Medical’s successful grant application to the Horizon Europe EIC Accelerator program. This program employs a unique hybrid grant-equity scheme to fund European pioneering innovations. In addition to a €2.5 million grant to support technology development, the European Union will also directly invest in iThera Medical via the EIC Fund. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care.
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The most trusted, influential source of new medical knowledge and clinical best practices in the world. Optoacoustic imaging offers a multitude of applications.Medical scanning technology company iThera Medical has announced successful closure of €13 million investment round, led by Trumpf Venture with participation by the EIC Fund as co-investor in addition to existing investors Mey Capital Matrix, Wachstumsfonds Bayern, BayBG, Fluxunit, Falk Strascheg Holding, and Occident. Wang, L. V. & Hu, S. Photoacoustic tomography: In vivo imaging from organelles to organs. Science 335, 1458–1462 (2012). Buehler, A., Kacprowicz, M., Taruttis, A. & Ntziachristos, V. Real-time handheld multispectral optoacoustic imaging. Opt. Lett. 38, 1404–1406 (2013).
de la Zerda, A. et al. Family of enhanced photoacoustic imaging agents for high-sensitivity and multiplexing studies in mice. ACS Nano. 6, 4694–4701 (2012). Nie, L. et al. In vivo volumetric photoacoustic molecular angiography and therapeutic monitoring with targeted plasmonic nanostars. Small (2013). 10.1002/smll.201302924.Inés, Y. E. et al. Biodistribution of phototherapeutic properties of zinc (II) 2, 9, 16, 23-tetrakis (methooxy) phthalocyanine in vivo. Photodiagn. Photodyn. Therapy. 6, 62–70 (2009).
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