Esoxx One x 14 sachets - Relief for Heartburn, Epigastric Pain, Reflux of Gastric, Epigastric Pain Description:

Gastroesophageal reflux, or acid reflux, occurs when the acid produced naturally by the stomach spreads from the stomach to the esophagus. Gastroesophageal reflux can be caused by hyperacidity or a drastic change in eating habits. Gastroesophageal reflux disease (GERD) causes heartburn. Esoxx ® (Alfa Wassermann, Bologna, Italy) is a new medical device for the topical treatment of the symptoms of gastroesophageal reflux disease (GERD). The product is based on a mixture of hyaluronic acid (HA) and chondroitin sulfate (CS) in a bioadhesive carrier Lutrol ® F 127 (poloxamer 407) (BASF, Milan, Italy), which acts as a buffering agent to form a barrier and to prolong the action on esophageal mucosa. 1 hyaluronic acid, chondroitin sulfate, polyvinylpyrrolidone, C xylitol, sodium benzoate, potassium sorbate, flavors, demineralized water, poloxamer 407. Esoxx One combines the properties of chondroitin, hyaluronic acid and a polymer to adhere, relieve and promote healing of the esophageal mucosa The results showed that Esoxx perfused at 1 mL/minute for 10 minutes, after mucosal damage induction, preventing the penetration of the EB dye in the mucosa and acting as a topical mucosal barrier.Esoxx One not be used in case of hypersensitivity to any component of the formulation. Not recommended for use in pregnant women and lactating mothers.

Thanks to its original and innovative formula, it acts mechanically, exerting a protective mucoadhesive action, and promoting healing. It thus provides rapid relief from pain. A NEW THERAPEUTIC APPROACHHyaluronic acid, an essential component of epithelia, is a pivotal molecule in the healing process and plays an important role in lubrication, cell differentiation and cell growth We found that the most severe lesions, characterized by erosions involving more than 50% of mucosal area and extending through more than 50% of the epithelial stratified layer, were observed in all the specimens perfused with acid solution for 90 minutes or with acid plus pepsin for 60 minutes. We considered this a suitable and reproducible model to induce a chemical lesion of esophageal mucosa.